Molecule of the Month December 2003 |
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Crystal Structure of the Citrobacter freundii Dihydroxyacetone Kinase Reveals an Eight-stranded a-Helical Barrel ATP-binding Domain | ||
This is the nucleotide binding domain of the dihydroxyacetone kinase of Citrobacter freundii complexed with AMPPNP (red) and a phospholipid (green). Met and Phe (yellow) separate the nucleotide-binding depression from the lipid-binding pocket of the eight-helix barrel. Homologous domains occur in the PTS-dependent kinase of E.coli and proteins associated with various transcription factors. This work was carried out in the group of Prof. Bernhard Erni. References:
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