A highly stable, 1,3-butadiene-derived DNA hairpin mimic has been synthesised. The modified hairpin was further derivatised with various dienophiles via the Diels-Alder reaction.

This work was carried out in the group of Prof. Robert Häner.

References:

• R. Tona, R. Häner;
  "Functionalisation of a diene-modified hairpin mimic via the Diels–Alder reaction"
  Chem. Commun., 1908-1909, (2004); doi:10.1039/B405223D.