Molecule of the Month
|A New Function for an Old Fold|
The enzymes of metabolic pathways have by and large been conserved in all kingdoms of life. In contrast, the mechanisms of pathway control are diverse. This is most obvious at the level of gene expression. The transcription of the dihydroxyacetone kinase genes in bacteria is one example of such diversity. The transcription factor DhaR from Lactococcus lactis belong to the TetR family. All 300 known members from this family are repressors of transcription that are inactivated by low molecular weight organic compounds.
This work was carried out in the group of Prof. Bernhard Erni.