Molecule of the Month
|Neoglycopeptide Dendrimer Libraries as a Source of Lectin Binding Ligands|
A 15'625-member peptide dendrimer combinatorial library was acylated with an a-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC50 = 11 ÁM) and Pseudomonas aeruginosa lectin PA-IIL (IC50 = 0.14 ÁM).
This work was carried out in the group of Prof. Jean-Louis Reymond.