Molecule of the Month
June 2007
Neoglycopeptide Dendrimer Libraries as a Source of Lectin Binding Ligands

A 15'625-member peptide dendrimer combinatorial library was acylated with an a-C-fucosyl residue at its four N-termini and screened for binding to fucose-specific lectins. Dendrimer FD2 was identified as a potent ligand against Ulex europaeus lectin UEA-I (IC50 = 11 ÁM) and Pseudomonas aeruginosa lectin PA-IIL (IC50 = 0.14 ÁM).
The dendrimer might be therapeutically useful for cystic fibrosis patients.

This work was carried out in the group of Prof. Jean-Louis Reymond.

References:

  • E. Kolomiets, E. M. V. Johansson, O. Renaudet, T. Darbre, J.-L. Reymond;
    "Neoglycopeptide Dendrimer Libraries as a Source of Lectin Binding Ligands."
    Org. Lett., 9, 1465-1468, (2007); doi:10.1021/ol070119d.