Molecule of the Month
December 2007
Human Blood Plasma Proteins: Structure and Function

Human plasma contains the most comprehensive version of the human proteome. The complexity of the ‘plasma proteome’ is quickly understood when one considers all the various forms of blood plasma proteins present in plasma: precursor and mature forms, splice variants, degradation products and of course all combinations of posttranslational modifications.
Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure.
Topics covered include:

Part I
1 Introduction
2 Blood Components
3 Blood Plasma Proteins
Part II
4 Domains, Motifs and Repeats
5 Protein Families
6 Posttranslational Modifications
Part III
7 Blood Coagulation and Fibrinolysis
8 The Complement System
9 The Immune System
10 Enzymes
11 Inhibitors
12 Lipoproteins
13 Hormones
14 Cytokines and Growth Factors
15 Transport and Storage
16 Additional Proteins

This work was carried out in the group of Prof. Johann Schaller.