Molecule of the Month
|Synthesis of (+)-Ferrugine|
The tropane alkaloid (+)-ferruginine was isolated from the extracts of two arboreal species Darlingia Darlingiana and Darlingia Ferruginea (photo). It is a potent neurotoxin of potential interest for the treatment of neurodegenerative disorders such as Alzheimer's disease. A facile synthesis of the naturally occuring (+)-ferrugine and of its enantiomer starting from commercially available achiral tropinone is reported.
This work was carried out in the group of Prof. Philippe Renaud.