Molecule of the Month
May 2008
CCGGTT + Cisplatin

Binding of platinum drugs,e.g. cis-(diaminodichloro)platinum(II), cisplatin, to oligonucleotides provides a basis of humnan cancer therapy.The platinum complex exhibits a unique dissociation behavior upon tandem mass spectrometric investigation.
Fundamental mechanistic aspects of the gas-phase dissociation of oligonucleotides and their analogues are in the focus of the mass spectrometry group at the Department of Chemistry and Biochemistry.

This work was carried out in the group of PD Dr. Stefan Schürch.