Molecule of the Month
|SMG6 PIN Domain is an Endonuclease that Cleaves Nonsense mRNAs|
Nonsense-mediated mRNA decay (NMD) is a translation-dependent mechanism to recognize and degrade mRNAs with termination codons in a molecular environment unfavorable for efficient translation termination. Among the previously identified trans-acting factors involved in NMD, the group of Oliver Mühlemann, in collaboration with Søren Lykke-Andersen and Torben Heick Jensen (Aarhus University, Denmark) identified human SMG6 as the endonuclease that cleaves nonsense mRNAs near the termination codon in the process of NMD (A; Eberle et al., 2009).
This work was carried out in the group of Prof. Oliver Mühlemann.