Molecule of the Month
|NMR Characterization of Opened Arene Ruthenium Metalla-Cubes|
This metalla-cube is highly cytotoxic, with an IC50 value of 2.1 mM against A2780 cancer cells and 3.8 mM against the cisplatin resistant A2780cisR cells. Its characterization by NMR spectroscopy was challenging: for the benzoquinone moiety, the impossibility to distinguish between closed 13C signals in a standard 1H-13C HSQC experiment is readily demonstrated (top), in which only two distinct cross peaks out of the six are identified.
The NMR investigation was carried out by Dr. Julien Furrer.