Molecule of the Month
|Loss of NCO- - A Novel Dissociation Pathway of Nucleic Acids|
Tandem mass spectrometry is a powerful analytical tool for the structural characterization of oligonucleotides. Highly charged oligonucleotides with a pyrimidine nucleobase in a terminal position were found to show a unique dissociation pattern.
This work was carried out by Rahel Eberle and Adrien Nyakas in the group of PD Dr. Stefan Schürch.