Molecule of the Month
March 2019
Targeting of the Mitochondrion by Dinuclear Thiolato-Bridged Arene Ruthenium Complexes in the Apicomplexan Parasite Neospora Caninum

Dinuclear-thiolato bridged arene ruthenium complexes inhibit the apicomplexan N. caninum proliferation with low IC50 values of up to 1 nM, but do not affect human foreskin fibroblast (HFF) host cells at dosages of 5 µM and above.
Biodistribution analysis using inductively coupled plasma mass spectrometry (ICP-MS) and transmission electron microscopy (TEM) showed that the parasite mitochondrion is the primary target in N. caninum tachyzoites.

This work was carried out in the group of Prof. Julien Furrer.


  • Afonso P. Basto, Nicoleta Anghel, Riccardo Rubbiani, Joachim Müller, David Stibal, Federico Giannini, Georg Süss-Fink, Vreni Balmer, Gilles Gasser, Julien Furrer, Andrew Hemphill;
    "Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum"
    Metallomics, 2019, 11(2), 462-474; doi:10.1039/c8mt00307f.