By SC ICP-MS quantification, it was shown that uptake of cisPt by A24 wild type cells is higher than the one of A24DPt8 cisPt resistant cells.
Nuclear cisPt concentration is higher than cellular cisPt in both wild type and resistant cell lines.
This work was carried out by the group of Prof. Peter Broekmann (DCBP) and Dr. Nico Ruprecht (Experimental Radiology, Inselspital Bern / Department for BioMedical Research (DBMR)).
A. Galé, L. Hofmann, N. Lüdi, M. N. Hungerbühler, C. Kempf, J. T. Heverhagen, H. von Tengg-Kobligk, P. Broekmann, N. Ruprecht;
"Beyond Single-Cell Analysis of Metallodrugs by ICP-MS: Targeting Cellular Substructures"
Int. J. Mol. Sci., 2021, 22(17), 9468/1-12;