Molecule of the Month October 2022 |
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A Small RNA with Big Regulatory Power | ||
We identified a 35-residue long bacterial non-coding RNA (FimR2) during stationary phase that is capable of simultaneously modulating biofilm formation, cell motility and virulence. To do so, FimR2 utilizes its single-stranded region to hybridize to several mRNA targets and uses its hairpin-structure for sequestration of the regulatory protein CsrA.
This work was carried out by Nicole Raad & colleagues in the group of Prof. Norbert Polacek in the context of the NCCR "RNA and Disease". References:
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