There are currently fewer than 10 antifungal drugs in clinical development, but new fungal strains that are resistant to most current antifungals are spreading rapidly across the world.
We tested a library of over 1000 metal complexes and found them to be highly active against relevant fungal strains. Only 1/11 metal compounds showed signs of toxicity in the Galleria mellonella animal model and one platinum compound was effective at treating a fungal infection in vivo.

This work was carried out in the group of SNSF Ambizione Fellow Dr. Angelo Frei.

References:

• A. Frei, A. G. Elliott, A. Kan, H. Dinh, S. Bräse, A. E. Bruce, M. R. Bruce, F. Chen, D. Humaidy, N. Jung, A. Paden King, P. G. Lye, H. K. Maliszewska, A. M. Mansour, D. Matiadis, M. Paz Muñoz, T.-Yu Pai, S. Pokhrel, P. J. Sadler, M. Sagnou, M. Taylor, J. J. Wilson, D. Woods, J. Zuegg, W. Meyer, A. K. Cain, M. A. Cooper, M. A. T. Blaskovich;
  "Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments"
  JACS Au, 2022, 2(10), 2277-2294; doi:10.1021/jacsau.2c00308.