Molecule of the Month
June 2024
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Unlocking the Metalation Applications of Superbasic Fe and Co(II) bis(amides)

Reversing the more usual trend of replicating transition metal chemistry with main group compounds, this work elaborates the applications of the new earth-abundant d-block amides Fe(TMP)2 and Co(TMP)2 in deprotonative metalation chemistry, a field dominated by highly polar s-block amides such as LiTMP (TMP=2,2,6,6-tetramethylpiperidide).

This work was carried out in the group of Prof. Dr. Eva Hevia.

References:

  • A. Logallo, L. C. H. Maddock, M. Mu, L. Gravogl, N. Jin, M. N. Penas-Defrutos, K. Meyer, M. Garcia-Melchor, E. Hevia;
    "Unlocking the Metalation Applications of TMP-powered Fe and Co(II) bis(amides): Synthesis, Structure and Mechanistic Insights"
    Angew. Chem. Int. Ed., 2024, 63, e202402907; doi:10.1002/anie.202402907.