Molecule of the Month
|Design and Synthesis of Small Drug-Like Molecules|
Diversity-oriented oligomerization of hydroxyaromatic aldehydes and ketones by oxime and ether bond formation leads to a diversity of drug-like molecules. The crystal structure of an ether oligomer is shown above. Micromolar inhibitors of proteases were readily discovered in a 140-member library. These new class of compounds are promising leads for drug discovery.
This work was carried out in the group of Prof. Jean-Louis Reymond.