Molecule of the Month January 2009 |
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Screening the Structural Space of Bicyclo-DNA:
Synthesis and Thermal Melting Properties of bc4,3-DNA |
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The picture shows two low energy conformations of monomeric units of [4.3.0]-bicyclo-DNA, a conformationally restricted DNA analogue. As part of her PhD, Andrea Stauffiger realized the synthesis of the modified DNA-building block, investigated the nucleoside structure by X-ray crystallography and determined the thermal melting properties of oligonucleotides.
This work was carried out in the group of Prof. Christian Leumann. References:
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