Molecule of the Month
October 2010
A Parallel Screen for the Discovery of Novel DNA Base-Pairs

A combinatorial assay based on a library of heterocyclic aromatic amines and an abasic DNA duplex was developed to identify novel molecules that recognize natural bases with high efficiency and selectivity. Out of a library of 34 amines the three shown in red were found to bind preferentially cytosine.

This work was carried out by Özlem Yaren in the group of Prof. Christian Leumann.