Molecule of the Month
March 2012
Tooth Morphology Biomimicry by Brushite Crystallization in Gelatin

Enamel is one of the major tissues that is assembled as needlelike crystals, bundled in parallel ordered prisms. Here, we develop a new method for biomimicking of tooth enamel using crystal nucleation and growth in gelatin by single diffusion technique. To this end, brushite crystals were grown by precipitation of calcium hydrogen phosphate hydrate in gelatin using glutamic acid as accelerator.
In conclusion, the prepared brushite crystals might open a new way to develop in-vitro teeth regeneration.

This work was carried out by Dr. Mazeyar Parvinzadeh Gashti, group of Prof. Jürg Hulliger.


  • K. Rajendran, C. Dale Keefe;
    "Growth and characterization of calcium hydrogen phosphate dihydrate crystals from single diffusion gel technique"
    Cryst. Res. Technol., 45, 939-945, (2010); doi:10.1002/crat.200900700.