Molecule of the Month
|Selenocysteine Biosynthesis in Eukaryotes: A Three Step Pathway|
The micronutrient selenium is found in proteins as selenocysteine (Sec), the 21st amino acid cotranslationally inserted in response to a UGA codon. The eukaryotic pathway for selenocysteinyl-tRNASec formation has been elusive for many years. Using the parasitic protozoa Trypanosoma brucei as a model system we were able to solve this problem.
This work was carried out in the group of Prof. André Schneider.