Molecule of the Month
January 2024
Discovery of Antibacterial Manganese Tricarbonyl Complexes

420 new manganese tricarbonyl complexes were prepared through combinatorial synthesis and investigated for their antibacterial properties. 10 promising compounds were re-synthesized and fully characterised identifying a promising lead compound with high activity against Gram-positive bacteria and low toxicity against healthy cells.
Release of the CO-ligands at the bacterial membrane, thereby inhibiting cellular respiration was identified as a possible mode of action.

This work was carried out in the group of Dr. Angelo Frei.


  • M. Scaccaglia, G. Pelosi, S. Pienlli, A. Frei;
    "Discovery of Antibacterial Manganese(I) Tricarbonyl Complexes through Combinatorial Chemistry"
    ChemRxiv, 2023, preprint; doi:10.26434/chemrxiv-2023-r66jc-v2.